Every competitive match Manchester United played in 2000–01 — 54 matches, 32 won, 12 drawn, 10 lost, with scorers and attendances where the record holds them.
| Date | Competition | Venue | Opponent | Their season | Score | Scorers | Att |
|---|---|---|---|---|---|---|---|
| 20 Aug 2000 | Premier League | H | Newcastle United | Newcastle United 2000–01 | 2–0 | Ronny Johnsen 20, Andy Cole 69 | 67,477 |
| 22 Aug 2000 | Premier League | A | Ipswich Town | Ipswich Town 2000–01 | 1–1 | David Beckham 39 | 22,007 |
| 26 Aug 2000 | Premier League | A | West Ham United | West Ham United 2000–01 | 2–2 | David Beckham 6, Andy Cole 49 | 25,998 |
| 5 Sep 2000 | Premier League | H | Bradford City | Bradford City 2000–01 | 6–0 | Andy Cole 11, Quinton Fortune 23, Quinton Fortune 60, Teddy Sheringham 71, Teddy Sheringham 81, David Beckham 85 | 67,447 |
| 9 Sep 2000 | Premier League | H | Sunderland | Sunderland 2000–01 | 3–0 | Paul Scholes 14, Teddy Sheringham 76, Paul Scholes 82 | 67,503 |
| 13 Sep 2000 | Champions League | H | R.S.C. Anderlecht | 5–1 | Andy Cole 15, Denis Irwin 31, Teddy Sheringham 42, Andy Cole 50, Andy Cole 72 | 62,749 | |
| 16 Sep 2000 | Premier League | A | Everton | Everton 2000–01 | 3–1 | Nicky Butt 26, Ryan Giggs 29, Ole Gunnar Solskjær 38 | 38,541 |
| 19 Sep 2000 | Champions League | A | Dynamo Kyiv | 0–0 | 65,000 | ||
| 23 Sep 2000 | Premier League | H | Chelsea | Chelsea 2000–01 | 3–3 | Paul Scholes 14, Teddy Sheringham 37, David Beckham 39 | 67,568 |
| 26 Sep 2000 | Champions League | A | PSV Eindhoven | 1–3 | Paul Scholes 2 | 30,500 | |
| 1 Oct 2000 | Premier League | A | Arsenal | Arsenal 2000–01 | 0–1 | 38,146 | |
| 14 Oct 2000 | Premier League | A | Leicester City | Leicester City 2000–01 | 3–0 | Teddy Sheringham 37, Teddy Sheringham 54, Ole Gunnar Solskjær 90 | 22,132 |
| 18 Oct 2000 | Champions League | H | PSV Eindhoven | 3–1 | Teddy Sheringham 8, Paul Scholes 82, Dwight Yorke 87 | 66,313 | |
| 21 Oct 2000 | Premier League | H | Leeds United | Leeds United 2000–01 | 3–0 | Dwight Yorke 40, David Beckham 50, Matt Jones 82 | 67,523 |
| 24 Oct 2000 | Champions League | A | R.S.C. Anderlecht | 1–2 | Denis Irwin 36 | 22,506 | |
| 28 Oct 2000 | Premier League | H | Southampton | Southampton 2000–01 | 5–0 | Andy Cole 9, Teddy Sheringham 45, Teddy Sheringham 51, Teddy Sheringham 55, Andy Cole 73 | 67,581 |
| 31 Oct 2000 | League Cup | A | Watford | Watford 2000–01 | 3–0 | ||
| 4 Nov 2000 | Premier League | A | Coventry City | Coventry City 2000–01 | 2–1 | Andy Cole 27, David Beckham 37 | 21,079 |
| 8 Nov 2000 | Champions League | H | Dynamo Kyiv | 1–0 | Teddy Sheringham 18 | 66,776 | |
| 11 Nov 2000 | Premier League | H | Middlesbrough | Middlesbrough 2000–01 | 2–1 | Nicky Butt 62, Teddy Sheringham 65 | 67,576 |
| 18 Nov 2000 | Premier League | A | Manchester City | Manchester City 2000–01 | 1–0 | David Beckham 2 | 34,429 |
| 21 Nov 2000 | Champions League | H | Panathinaikos | 3–1 | Teddy Sheringham 48, Paul Scholes 81, Paul Scholes 90 | 65,024 | |
| 25 Nov 2000 | Premier League | A | Derby County | Derby County 2000–01 | 3–0 | Teddy Sheringham 61, Nicky Butt 69, Dwight Yorke 76 | 32,910 |
| 28 Nov 2000 | League Cup | A | Sunderland | Sunderland 2000–01 | 1–2 | Dwight Yorke 30 | |
| 2 Dec 2000 | Premier League | H | Tottenham Hotspur | Tottenham Hotspur 2000–01 | 2–0 | Paul Scholes 40, Ole Gunnar Solskjær 84 | 67,583 |
| 6 Dec 2000 | Champions League | A | SK Sturm Graz | 2–0 | Paul Scholes 18, Ryan Giggs 89 | 16,500 | |
| 9 Dec 2000 | Premier League | A | Charlton Athletic | Charlton Athletic 2000–01 | 3–3 | Ryan Giggs 42, Ole Gunnar Solskjær 43, Roy Keane 66 | 20,043 |
| 17 Dec 2000 | Premier League | H | Liverpool | Liverpool 2000–01 | 0–1 | 67,533 | |
| 23 Dec 2000 | Premier League | H | Ipswich Town | Ipswich Town 2000–01 | 2–0 | Ole Gunnar Solskjær 20, Ole Gunnar Solskjær 32 | 67,597 |
| 26 Dec 2000 | Premier League | A | Aston Villa | Aston Villa 2000–01 | 1–0 | Ole Gunnar Solskjær 85 | 40,889 |
| 30 Dec 2000 | Premier League | A | Newcastle United | Newcastle United 2000–01 | 1–1 | David Beckham 25 | 52,134 |
| 1 Jan 2001 | Premier League | H | West Ham United | West Ham United 2000–01 | 3–1 | Ole Gunnar Solskjær 3, Stuart Pearce 33, Dwight Yorke 57 | 67,603 |
| 7 Jan 2001 | FA Cup | A | Fulham | Fulham 2000–01 | 2–1 | Ole Gunnar Solskjær 8, Teddy Sheringham 89 | |
| 13 Jan 2001 | Premier League | A | Bradford City | Bradford City 2000–01 | 3–0 | Teddy Sheringham 72, Ryan Giggs 75, Luke Chadwick 87 | 20,551 |
| 20 Jan 2001 | Premier League | H | Aston Villa | Aston Villa 2000–01 | 2–0 | Gary Neville 57, Teddy Sheringham 87 | 67,533 |
| 28 Jan 2001 | FA Cup | H | West Ham United | West Ham United 2000–01 | 0–1 | ||
| 31 Jan 2001 | Premier League | A | Sunderland | Sunderland 2000–01 | 1–0 | Andy Cole 46 | 48,260 |
| 3 Feb 2001 | Premier League | H | Everton | Everton 2000–01 | 1–0 | Steve Watson 52 | 67,528 |
| 10 Feb 2001 | Premier League | A | Chelsea | Chelsea 2000–01 | 1–1 | Andy Cole 69 | 34,960 |
| 14 Feb 2001 | Champions League | A | Valencia CF | 0–0 | 49,541 | ||
| 20 Feb 2001 | Champions League | H | Valencia CF | 1–1 | Andy Cole 12 | 66,715 | |
| 25 Feb 2001 | Premier League | H | Arsenal | Arsenal 2000–01 | 6–1 | Dwight Yorke 3, Dwight Yorke 18, Dwight Yorke 22, Roy Keane 26, Ole Gunnar Solskjær 38, Teddy Sheringham 90 | 67,535 |
| 3 Mar 2001 | Premier League | A | Leeds United | Leeds United 2000–01 | 1–1 | Luke Chadwick 64 | 40,055 |
| 7 Mar 2001 | Champions League | A | Panathinaikos | 1–1 | Paul Scholes 90 | 27,231 | |
| 13 Mar 2001 | Champions League | H | SK Sturm Graz | 3–0 | Nicky Butt 5, Teddy Sheringham 20, Roy Keane 86 | 66,404 | |
| 17 Mar 2001 | Premier League | H | Leicester City | Leicester City 2000–01 | 2–0 | Dwight Yorke 88, Mikaël Silvestre 90 | 67,516 |
| 31 Mar 2001 | Premier League | A | Liverpool | Liverpool 2000–01 | 0–2 | 44,806 | |
| 10 Apr 2001 | Premier League | H | Charlton Athletic | Charlton Athletic 2000–01 | 2–1 | Andy Cole 45, Ole Gunnar Solskjær 82 | 67,505 |
| 14 Apr 2001 | Premier League | H | Coventry City | Coventry City 2000–01 | 4–2 | Dwight Yorke 13, Dwight Yorke 28, Ryan Giggs 81, Paul Scholes 87 | 67,637 |
| 21 Apr 2001 | Premier League | H | Manchester City | Manchester City 2000–01 | 1–1 | Teddy Sheringham 71 | 67,535 |
| 28 Apr 2001 | Premier League | A | Middlesbrough | Middlesbrough 2000–01 | 2–0 | Phil Neville 4, David Beckham 84 | 34,417 |
| 5 May 2001 | Premier League | H | Derby County | Derby County 2000–01 | 0–1 | 67,526 | |
| 13 May 2001 | Premier League | A | Southampton | Southampton 2000–01 | 1–2 | Ryan Giggs 71 | 15,526 |
| 19 May 2001 | Premier League | A | Tottenham Hotspur | Tottenham Hotspur 2000–01 | 1–3 | Paul Scholes 22 | 36,072 |
103 of the goals in this season carry a named scorer.
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