Every competitive match Leicester City played in 2000–01, in Premier League — 45 matches, 17 won, 7 drawn, 21 lost, with scorers and attendances where the record holds them.
| Date | Competition | Venue | Opponent | Their season | Score | Scorers | Att |
|---|---|---|---|---|---|---|---|
| 19 Aug 2000 | Premier League | H | Aston Villa | Aston Villa 2000–01 | 0–0 | 21,455 | |
| 23 Aug 2000 | Premier League | A | West Ham United | West Ham United 2000–01 | 1–0 | Darren Eadie 53 | 25,195 |
| 26 Aug 2000 | Premier League | A | Bradford City | Bradford City 2000–01 | 0–0 | 16,766 | |
| 6 Sep 2000 | Premier League | H | Ipswich Town | Ipswich Town 2000–01 | 2–1 | Ade Akinbiyi 57, Matt Elliott 73 | 19,598 |
| 9 Sep 2000 | Premier League | H | Southampton | Southampton 2000–01 | 1–0 | Gerry Taggart 66 | 18,366 |
| 14 Sep 2000 | UEFA Cup | H | Red Star Belgrade | 1–1 | Gerry Taggart 43 | 20,190 | |
| 17 Sep 2000 | Premier League | A | Chelsea | Chelsea 2000–01 | 2–0 | Muzzy Izzet 8, Stan Collymore 82 | 33,697 |
| 24 Sep 2000 | Premier League | H | Everton | Everton 2000–01 | 1–1 | Ade Akinbiyi 23 | 18,084 |
| 28 Sep 2000 | UEFA Cup | A | Red Star Belgrade | 1–3 | Muzzy Izzet 42 | 12,700 | |
| 1 Oct 2000 | Premier League | A | Sunderland | Sunderland 2000–01 | 0–0 | 45,338 | |
| 14 Oct 2000 | Premier League | H | Manchester United | Manchester United 2000–01 | 0–3 | 22,132 | |
| 21 Oct 2000 | Premier League | A | Liverpool | Liverpool 2000–01 | 0–1 | 44,395 | |
| 28 Oct 2000 | Premier League | H | Derby County | Derby County 2000–01 | 2–1 | Muzzy Izzet 31, Arnar Gunnlaugsson 76 | 20,525 |
| 1 Nov 2000 | League Cup | H | Crystal Palace | Crystal Palace 2000–01 | 0–3 | 12,965 | |
| 4 Nov 2000 | Premier League | A | Manchester City | Manchester City 2000–01 | 1–0 | Robbie Savage 56 | 34,279 |
| 11 Nov 2000 | Premier League | H | Newcastle United | Newcastle United 2000–01 | 1–1 | Arnar Gunnlaugsson 63 | 21,406 |
| 18 Nov 2000 | Premier League | A | Middlesbrough | Middlesbrough 2000–01 | 3–0 | Muzzy Izzet 8, Trevor Benjamin 13, Darren Eadie 57 | 27,965 |
| 25 Nov 2000 | Premier League | A | Tottenham Hotspur | Tottenham Hotspur 2000–01 | 0–3 | 35,636 | |
| 2 Dec 2000 | Premier League | H | Leeds United | Leeds United 2000–01 | 3–1 | Robbie Savage 8, Ade Akinbiyi 17, Gerry Taggart 29 | 21,486 |
| 10 Dec 2000 | Premier League | A | Coventry City | Coventry City 2000–01 | 0–1 | 17,283 | |
| 16 Dec 2000 | Premier League | H | Charlton Athletic | Charlton Athletic 2000–01 | 3–1 | Ade Akinbiyi 35, Matt Elliott 79, Arnar Gunnlaugsson 90 | 19,371 |
| 23 Dec 2000 | Premier League | H | West Ham United | West Ham United 2000–01 | 2–1 | Muzzy Izzet 26, Robbie Savage 63 | 21,524 |
| 26 Dec 2000 | Premier League | A | Arsenal | Arsenal 2000–01 | 1–6 | Ade Akinbiyi 54 | 38,007 |
| 1 Jan 2001 | Premier League | H | Bradford City | Bradford City 2000–01 | 1–2 | Muzzy Izzet 38 | 19,278 |
| 6 Jan 2001 | FA Cup | H | York City | 3–0 | Gary Rowett 57, Muzzy Izzet 63, Richard Cresswell 73 | 16,850 | |
| 14 Jan 2001 | Premier League | A | Ipswich Town | Ipswich Town 2000–01 | 0–2 | 22,022 | |
| 20 Jan 2001 | Premier League | H | Arsenal | Arsenal 2000–01 | 0–0 | 21,872 | |
| 27 Jan 2001 | FA Cup | A | Aston Villa | Aston Villa 2000–01 | 2–1 | Ade Akinbiyi 42, Arnar Gunnlaugsson 84 | 26,383 |
| 31 Jan 2001 | Premier League | A | Southampton | Southampton 2000–01 | 0–1 | 14,909 | |
| 3 Feb 2001 | Premier League | H | Chelsea | Chelsea 2000–01 | 2–1 | Muzzy Izzet 24, Gary Rowett 76 | 21,502 |
| 10 Feb 2001 | Premier League | A | Everton | Everton 2000–01 | 1–2 | Dean Sturridge 79 | 30,409 |
| 17 Feb 2001 | FA Cup | H | Bristol City | Bristol City 2000–01 | 3–0 | Dean Sturridge 10, Matt Hill 15, Muzzy Izzet 83 | 20,905 |
| 24 Feb 2001 | Premier League | H | Sunderland | Sunderland 2000–01 | 2–0 | Dean Sturridge 30, Ade Akinbiyi 65 | 21,086 |
| 3 Mar 2001 | Premier League | H | Liverpool | Liverpool 2000–01 | 2–0 | Ade Akinbiyi 51, Muzzy Izzet 90 | 21,924 |
| 10 Mar 2001 | FA Cup | H | Wycombe Wanderers | Wycombe Wanderers 2000–01 | 1–2 | Muzzy Izzet 68 | 21,969 |
| 17 Mar 2001 | Premier League | A | Manchester United | Manchester United 2000–01 | 0–2 | 67,539 | |
| 1 Apr 2001 | Premier League | A | Charlton Athletic | Charlton Athletic 2000–01 | 0–2 | 20,043 | |
| 4 Apr 2001 | Premier League | A | Aston Villa | Aston Villa 2000–01 | 1–2 | Callum Davidson 27 | 29,043 |
| 7 Apr 2001 | Premier League | H | Coventry City | Coventry City 2000–01 | 1–3 | Ade Akinbiyi 10 | 19,545 |
| 14 Apr 2001 | Premier League | H | Manchester City | Manchester City 2000–01 | 1–2 | Ade Akinbiyi 41 | 20,224 |
| 16 Apr 2001 | Premier League | A | Derby County | Derby County 2000–01 | 0–2 | 28,387 | |
| 21 Apr 2001 | Premier League | H | Middlesbrough | Middlesbrough 2000–01 | 0–3 | 18,162 | |
| 28 Apr 2001 | Premier League | A | Newcastle United | Newcastle United 2000–01 | 0–1 | 50,501 | |
| 5 May 2001 | Premier League | H | Tottenham Hotspur | Tottenham Hotspur 2000–01 | 4–2 | Gary Rowett 42, Dean Sturridge 56, Steve Guppy 82, Robbie Savage 90 | 21,056 |
| 19 May 2001 | Premier League | A | Leeds United | Leeds United 2000–01 | 1–3 | Rio Ferdinand 32 | 39,105 |
50 of the goals in this season carry a named scorer.
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