Wrexham have played Southampton 9 times in competitive football, winning 3, drawing 0 and losing 6, first meeting on 27 Sep 1958 and most recently on 7 Apr 2026. Every meeting is listed below.
| Date | Season | Competition | Venue | Opponent | Score | Scorers | Att |
|---|---|---|---|---|---|---|---|
| 27 Sep 1958 | 1958–59 | Third Division | A | Southampton | 2–1 | ||
| 14 Feb 1959 | 1958–59 | Third Division | H | Southampton | 1–3 | ||
| 21 Nov 1959 | 1959–60 | Third Division | A | Southampton | 0–3 | ||
| 9 Apr 1960 | 1959–60 | Third Division | H | Southampton | 2–1 | ||
| 16 Feb 1974 | 1973–74 | FA Cup | A | Southampton | 1–0 | ||
| 28 Aug 1979 | 1979–80 | League Cup | A | Southampton | 0–5 | ||
| 5 Sep 1979 | 1979–80 | League Cup | H | Southampton | 0–3 | ||
| 9 Aug 2025 | 2025–26 | Championship | A | Southampton | 1–2 | Windass Cleworth McClean 22 | 30,970 |
| 7 Apr 2026 | 2025–26 | Championship | H | Southampton | 1–5 | Windass Doyle Longman 34 | 10,547 |
See also: the Southampton archive and Southampton v Wrexham.